Tumor-infiltrating CD8 T cells from B16.F10 melanoma tumor-bearing C57BL/6 PMEL (n=3) (Jackson Laboratory, Cat#005023) mice were sorted by flow cytometry 15 days post-tumor engraftment. Paired transciptomic profiles and TCR sequences were obtained at single-cell resolution using 10X Genomics Chromium technology. GEO SERIES https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE116390 datasets PMEL1, PMEL2 and PMEL3 (replicates)